Table 2.

Differentiation of SJIA versus bacterial infections and NOMID with S100A12 at various cut-offs.

Parameter	Area under the curve	Cut-off	Sensitivity	Specificity	Positive Likelihood ratio
SJIA vs infections	0.881 ± 0.078	800 ng/ml	85%	89%	7.7
	1400 ng/ml	66%	94%	11.0
	2750 ng/ml	55%	97%	18.3
SJIA vs NOMID	0.866 ± 0.084	800 ng/ml	84%	72%	3.0
	1400 ng/ml	66%	89%	6.0
	2750 ng/ml	54%	94%	9.0
SJIA vs MWS	0.972 ± 0.031	1000 ng/ml	78%	100%	n.a.
SJIA vs ALL	0.981 ± 0.024	1000 ng/ml	78%	100%	n.a.
SJIA vs AML	1.000 ± 0.0	150 ng/ml	97%	100%	n.a.
SJIA vs healthy controls	0.994 ± 0.012	150 ng/ml	98%	100%	n.a.

vs=versus; n.a.=not applicable, LR+ is going to infinity in these cases