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Inhibitory effect of UK 14,304 on ICa2+. A, Activation of α2-adrenoceptors with UK 14,304 inhibited ICa2+. ICa2+ was activated by depolarizing the membrane potential from −70 mV to −10 mV. B, Concentration-response relationship for UK 14,304 induced inhibition of ICa2+. Inhibition of ICa2+ is plotted as amplitude in the presence of each concentration of UK 14,304 normalized to the control ICa2+. Points represent the mean ± s.e.m. of data from 4−7 cells.
