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. Author manuscript; available in PMC: 2009 May 11.
Published in final edited form as: Neurogastroenterol Motil. 2007 Oct;19(10):845–855. doi: 10.1111/j.1365-2982.2007.00976.x

Figure 2.

Figure 2

Inhibitory effect of UK 14,304 on ICa2+ in the presence of the L-type channel antagonist, nifedipine. A, Representative recordings of ICa2+ showing a reduction by nifedipine and a further inhibition by addition of UK 14,304. B, Effect of UK14,304 (1 μM) to ICa2+ in the presence of nifedipine (1 μM). Currents recorded in the presence of nifedipine and UK 14,304 were normalized to the control current in the same neuron. The inhibitory effects of UK 14,304 were reversible on washing with nifedipine-containing Krebs’ solution (n = 4). ICa2+ was activated by depolarizing the membrane potential from −70 mV to −10 mV.