Inhibitory effect of UK 14,304 on ICa2+ in the presence of an N-type Ca2+ channel toxin. A, UK 14,304 inhibited ICa2+ in the presence of CTX. ICa2+ was activated by depolarizing the membrane potential from −70 mV to −10 mV. B, Inhibitory effect of UK 14,304 on ICa2+ in the presence of CTX. CTX inhibited ICa2+ (P < 0.05) and UK 14.304 (1 μM) produced a further reduction in current amplitude (P < 0.05, n = 8). Currents recorded in the presence of CTX with 14,304 were normalized to the current recorded in the presence of CTX in the same neuron.