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PTX blocks the inhibitory effect of UK 14,304 on ICa2+. A, The inhibitory effect of UK 14,304 (1 μM) on ICa2+ was blocked by PTX. ICa2+ activated by depolarizing the membrane potential to − 10 mV from a holding potential of −70 mV. B, PTX pretreatment blocks UK 14,304-induced inhibition of ICa2+. ICa2+ was plotted as the mean current normalized to current amplitude before UK 14,304 application. Data are mean ± s.e.m. (n = 5).
