Resveratrol extends lifespan in an AMPK-dependent, but FoxO-independent, manner. (A) Resveratrol (100 µm) extended WT (N2) worm lifespan (14.2%, P = 0.0005), but did not significantly extend aak-2(ok524) mutant worm lifespan (2.2%P = 0.5485). Mean, standard errors, and statistical analysis for three independent experiments performed in triplicate are presented in Table S5. (B) Resveratrol (100 µm) extended both WT (N2) worm lifespan (14.6%P < 0.0001) and daf-16(mu86) mutant worm lifespan (13.7%P < 0.0001). Res, resveratrol. Mean, standard errors, and statistical analysis for one experiment performed in triplicate are presented in Table S5.