Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Cartoon representation of classical vs. CBI antagonism of ER. A. Conformation of agonist-bound ER with helix 12 forming part of the steroid receptor coactivator (SRC) binding site; B. Conformation of antagonist-bound ER in which helix 12 occupies the SRC binding site, disrupting the ER/SRC interaction indirectly; C, Conformation of agonist-bound ER in which a CBI occupies the SRC binding site, disrupting ER/SRC interaction directly.
