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. Author manuscript; available in PMC: 2009 Oct 23.
Published in final edited form as: J Med Chem. 2008 Sep 12;51(20):6512–6530. doi: 10.1021/jm800698b

Figure 5.

Figure 5

Coactivator binding inhibition assays. A, Dose-response of CBI inhibition of ER-mediated transcription in cell-based reporter gene assay run at two concentrations of estradiol; B, Plot of CBI Ki (μM) as calculated from in vitro TR-FRET assay vs. CBI IC50 as determined by cell-based reporter gene assay.