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. Author manuscript; available in PMC: 2010 Jan 15.
Published in final edited form as: Bioorg Med Chem Lett. 2008 Nov 18;19(2):485–488. doi: 10.1016/j.bmcl.2008.11.043

Scheme 3.

Scheme 3

(a) NaH, 4-iodobutylphthalimide, DMF, 0 °C to r.t., 83%; (b) EtSH, AlCl3, r.t., 85%; (c) TBDMSCl, imidazole, DMF, 91%; (d) H2NNH2, CH2Cl2, MeOH, r.t., 80%; (e) 21, CH2Cl2, THF, r.t., 80%; (f) H+, acetone, r.t., 72%; (g) - i.) NH2CH2CH2NHAc, CH2Cl2, ii.) NaBH4; (h) 1N HCl/MeOH, r.t., quant; (i) - i.) G-6 PAMAM, MeOH, Δ; ii.) NaBH4, quant.