. Author manuscript; available in PMC: 2010 Jan 15.

Published in final edited form as: Bioorg Med Chem Lett. 2008 Nov 18;19(2):485–488. doi: 10.1016/j.bmcl.2008.11.043

Table 2.

RBA values for tethered indole ligands

Compound #	Structure	ERα, ERβ relative binding affinity (RBA)
10	(See Scheme 2)	0.188, 0.084
11	(See Scheme 2)	2.17, 0.24
13	(See Scheme 2)	0.314, 0.046
15	(See Scheme 2)	0.226, 0.048
19		0.5±0.1, 0.1±0.1
20	(See Scheme 3)	1.3±0.2^a, <0.007^a

RBA values for the dendrimer conjugate are based on the concentration of ligand, not the dendrimer conjugate. Based on the dendrimer, RBA values would be 25-fold higher.