Skip to main content
. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: Cancer Res. 2008 Aug 1;68(15):6084–6091. doi: 10.1158/0008-5472.CAN-07-6854

Figure 3.

Figure 3

Effect of PTEN and PIK3CA mutations on AKT activation/phosphorylation at Ser473 in 40 breast cancer cell lines. AKT phosphorylation at Ser473 (AKTp473) was significantly higher in PTEN-mutant cell lines than in PIK3CA-mutant (P = 0.005) or PTEN/PIK3CA wild-type (P = 0.001) cell lines. In contrast, there was no significant difference (P = 0.64) in AKT phosphorylation at Ser473 between PIK3CA-mutant and PTEN/PIK3CA wild-type cell lines. AKTp473 was quantified using RPPA and expressed on the Y axis after logarithmic conversion and mean centering.