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. 1999 Mar 2;96(5):2451–2455. doi: 10.1073/pnas.96.5.2451

Figure 3.

Figure 3

Dysregulation of endogenous K+ channel gene expression in HypK transgenic mice. Representative autoradiograms of in situ hybridization of K+ channel subunit mRNA expression in adult FVB hippocampal control (+/+) (Upper) and HypK transgenic (Lower) mice. Kv1.2 mRNA expression is selectively down-regulated in the dentate gyrus of the HypK transgenic mouse, whereas Kv1.4 mRNA levels are up-regulated. Kvβ1 mRNA expression is down-regulated in the dentate gyrus and to a lesser degree in layers II/III of the overlying neocortex of the HypK transgenic mouse.