Table 1.

Regional K⁺ channel subunit expression changes in HYPK mutant brain

Region	Normalized subunit expression
	Kv1.1	Kv1.2	Kv1.3	Kv1.4	Kv1.5	Kv1.6	Kvβ1.1	Kvβ2
Dentate	1.06	0.41*	0.98	1.27*	0.65*	1.35*	0.59*	0.69*
Hilus	1.1	1.03	1.16	0.97	1.00	1.63*	0.89	1.00
CA2/3	0.94	0.96	1.54*	0.92	1.25*	1.72*	0.92	0.95
CA1	1.3	0.93	1.33*	0.99	1.55*	1.62*	0.9	0.73*
Cortex II/III	1.32*	0.78	1.12	1.00	1.48*	2.18*	0.75*	1.05
Cortex IV/VI	1.08	1.05	1.1	0.84	1.34*	1.7*	0.98	1.12

Values represent ratio of the mean optical density from triplicate densitometric determinations of each specific hybridized probe in HypK brain sections divided by those from matched +/+ brain sections. Regulation of native mRNA levels by AKv1.1a transgene expression was neither region nor subunit dependent. 

^*Levels in mutant brain altered by 25% or greater.