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Radioflow HPLC analysis of 65 μM [14C]coumarin metabolism by CYP2A13 (10 pmol; 30 min) (A and B) or CYP2A13 N297A (5 pmol; 20 min) (C and D). Reactions were carried out in the absence (A and C) or presence (B and D) of GSH and GST. Arrows in A indicate retention times of metabolite standards. The arrow in B to D indicate the retention time of 7-hydroxycoumarin. The asterisk (*) is the GSH/GST-dependent peak.
