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. 2008 Dec 23;37(3):469–478. doi: 10.1124/dmd.108.025155

TABLE 2.

Effect of 1α, 25-(OH)2-VD3 on total bile acid synthesis in HepG2 and primary human hepatocytes

Primary human hepatocytes (#HH1393, #HH1408, #HH1410) or HepG2 cells were treated with 1α, 25-(OH)2-VD3 (100 nM) for 24 h, and total bile acids synthesized in hepatocytes were assayed and expressed as the percentage of vehicle-treated control.

Cells Total Bile Acid Synthesis (% of control)
HepG2 67.3 ± 1.5
HH1393 51
HH1408 48
HH1393 59
Average human hepatocytes 52.7 ± 5.7