TABLE 1.

Percentage of dose recovered from tissues and excreta after oral administration of [¹⁴C]BMP (100 mg/kg) for 1, 5, or 10 daily administrations to male F-344 rats

Data are mean ± S.D.

	Fasted (72 ha): 1 Administration (n = 4)	Unfasted (24 ha)
		1 Administration (n = 3)	5 Administrations (n = 4)	10 Administrations (n = 4)
Adipose tissues	0.13 ± 0.05	0.18 ± 0.06	0.06 ± 0.02	0.04 ± 0.01
Bladder	0.00 ± 0.00	0.02 ± 0.01	0.01 ± 0.01	0.00 ± 0.00
Bladder urine	0.02 ± 0.02	0.60 ± 0.53	0.05 ± 0.03	0.03 ± 0.03
Blood	0.20 ± 0.02	0.34 ± 0.11	0.22 ± 0.04	0.17 ± 0.01
Brain	N.D.	0.01 ± 0.00	0.00 ± 0.00	0.00 ± 0.00
Cecum	0.01 ± 0.00	0.26 ± 0.07	0.11 ± 0.04	0.03 ± 0.00
Cecum contents	0.10 ± 0.05	4.08 ± 2.18	0.99 ± 0.33	0.35 ± 0.13
Cecum rinse	0.01 ± 0.01	0.55 ± 0.47	0.04 ± 0.03	0.01 ± 0.00
Heart	0.00 ± 0.00	0.00 ± 0.00	0.00 ± 0.00	0.00 ± 0.00
Intestine	0.05 ± 0.03	1.78 ± 0.95	0.49 ± 0.16	0.14 ± 0.05
Intestine contents	0.18 ± 0.06	7.23 ± 1.94	2.30 ± 0.24	0.99 ± 0.41
Kidneys	0.01 ± 0.00	0.05 ± 0.01	0.02 ± 0.00	0.01 ± 0.00
Liver	0.05 ± 0.01	0.65 ± 0.40	0.15 ± 0.04	0.09 ± 0.03
Lung	0.00 ± 0.00	0.01 ± 0.00	0.00 ± 0.00	0.00 ± 0.00
Muscle	0.20 ± 0.03	0.34 ± 0.29	0.27 ± 0.09	0.18 ± 0.02
Skin	0.11 ± 0.02	0.25 ± 0.06	0.12 ± 0.02	0.08 ± 0.01
Spleen	0.00 ± 0.00	0.00 ± 0.00	0.00 ± 0.00	0.00 ± 0.00
Stomach	0.00 ± 0.00	0.01 ± 0.01	0.01 ± 0.00	0.00 ± 0.00
Stomach contents	0.00 ± 0.00	0.01 ± 0.01	0.00 ± 0.00	0.00 ± 0.00
Testes	0.00 ± 0.00	0.01 ± 0.00	0.00 ± 0.00	0.00 ± 0.00
GI tract tissues	0.07 ± 0.03	2.05 ± 0.96	0.60 ± 0.21	0.18 ± 0.05
GI tract contents	0.29 ± 0.12	11.86 ± 3.98	3.33 ± 0.42	1.35 ± 0.43
Tissues total	0.89 ± 0.18	16.05 ± 5.72	4.63 ± 0.70	1.97 ± 0.49
Urine	58.05 ± 4.28	53.40 ± 9.43	30.39 ± 5.75	19.13 ± 6.21
Cage rinse	22.73 ± 5.20	17.32 ± 0.30	44.56 ± 3.41	58.23 ± 3.18
Feces	9.68 ± 1.93	7.86 ± 1.05	14.22 ± 3.48	14.51 ± 6.31
Excreta total	90.46 ± 1.49	78.62 ± 8.42	89.17 ± 3.37	91.88 ± 2.79
Total recovery	91.56 ± 1.67	95.01 ± 4.10	94.05 ± 3.26	94.02 ± 2.42

N.D., not determined.

^aTime after administration.