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ABCC2 expression represents a fragile node in CDF disposition within primary rat hepatocytes. Levels of each node was altered sequentially to 0.1, 05, 1, 5, and 10 units, relative to baseline model, within the in silico model, and CDFDA/CDF levels were simulated for a period of 3 min using a starting concentration of 0.1 to 2500 μM CDFDA in HBSS. The impact of these changes on Vmax and Km are shown.
