TABLE 1.
Dose recovered (%) in 72 h for male F-344 rats (R) and in 96 h for female B6C3F1 mice (M) after a single oral administration of [14C]NBuPy-Cl
Data are presented as mean ± S.E.M.
|
Dose Recovered
|
||||
|---|---|---|---|---|
| 0.5 mg/kgR, n = 4 | 5 mg/kgR, n = 4 | 50 mg/kgR, n = 8 | 50 mg/kgM, n = 6 | |
| % | % | % | % | |
| Feces | 25.0 ± 4.8 | 21.2 ± 2.7 | 25.9 ± 2.2 | 10.3 ± 1.2* |
| Urine | 62.3 ± 6.0 | 68.0 ± 2.5 | 66.7 ± 1.9 | 71.6 ± 5.0 |
| Blood | <0.05 | <0.05 | <0.05 | <0.05 |
| Total recovery | 87.3 ± 7.4 | 89.3 ± 3.8 | 92.5 ± 2.8 | 81.9 ± 4.3 |
p < 0.05 compared with rats dosed with 50 mg/kg NBuPy-Cl.