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. 2009 Jan 26;37(4):909–916. doi: 10.1124/dmd.108.022681

TABLE 1.

Dose recovered (%) in 72 h for male F-344 rats (R) and in 96 h for female B6C3F1 mice (M) after a single oral administration of [14C]NBuPy-Cl

Data are presented as mean ± S.E.M.

Dose Recovered
0.5 mg/kgR, n = 4 5 mg/kgR, n = 4 50 mg/kgR, n = 8 50 mg/kgM, n = 6
% % % %
Feces 25.0 ± 4.8 21.2 ± 2.7 25.9 ± 2.2 10.3 ± 1.2*
Urine 62.3 ± 6.0 68.0 ± 2.5 66.7 ± 1.9 71.6 ± 5.0
Blood <0.05 <0.05 <0.05 <0.05
Total recovery 87.3 ± 7.4 89.3 ± 3.8 92.5 ± 2.8 81.9 ± 4.3
*

p < 0.05 compared with rats dosed with 50 mg/kg NBuPy-Cl.