TABLE 3.

Concentration in nanomoles per gram of [¹⁴C]NBuPy-Cl equivalents in selected tissues (except blood, which was given in nmol/ml) at 24 h after a single oral administration or 24 h after the fifth daily oral administration of [¹⁴C]NBuPy-Cl (50 mg/kg/day) to male F-344 rats

Data are presented as mean ± S.E.M.

	NBuPy-Cl
	One Administration, n = 4	Five Administrations, n = 4
	nmol/g	nmol/g
Adipose	3.6 ± 0.7	3.5 ± 0.4
Blood (nmol/ml)	0.8 ± 0.1	3.2 ± 0.1*
Brain	0.5 ± 0.1	1.5 ± 0.3*
Gastrointestinal tract tissues	10.0 ± 1.0	20.9 ± 3.5*
Kidney	3.5 ± 0.3	7.7 ± 0.2*
Liver	5.1 ± 0.3	10.7 ± 0.2*
Muscle	10.1 ± 0.4	17.9 ± 1.1*
Skin	4.7 ± 0.8	10.5 ± 0.6*

^*p < 0.05 compared with single dose.