TABLE 2.
Summary of mouse Ugt mRNA expression in liver by activators of AhR, CAR, PXR, PPARα, and Nrf2
| AhR | CAR | PXR | PPARα | Nrf2 | |
|---|---|---|---|---|---|
| Ugt1a1 | ↑ | ↑ | ↑ | ↑ | ↑ |
| Ugt1a2 | — | — | — | — | — |
| Ugt1a5 | — | — | — | — | ↑ |
| Ugt1a6 | ↑ | — | ↑ | ↑ | ↑ |
| Ugt1a7 | — | — | — | — | — |
| Ugt1a9 | ↑ | ↑ | ↑ | ↑ | ↑ |
| Ugt1a10 | — | — | — | — | — |
| Ugt2a3 | ↓ | ↓ | — | — | — |
| Ugt2b1 | — | — | — | — | ↓ |
| Ugt2b5 | — | — | — | — | — |
| Ugt2b34 | — | — | — | — | — |
| Ugt2b35 | ↑ | — | — | — | — |
| Ugt2b36 | — | ↑ | ↑ | — | — |
| Ugt3a1/2 | — | — | — | — | — |
↑, Increased mRNA expression by two or more chemical activators.
↓, Decreased mRNA expression by two or more chemical activators.
—, Little or no change by chemical activators.