TABLE 2.
Pharmacokinetic parameters of rats receive a single oral dose of pure matrine or ACAPHAa
| Parameter | Pure Matrine | ACAPHA |
|---|---|---|
| BLPLR | 1.0 | 1.0 |
| ka (h-1) | 6.5 | 4.0 (4.0)b |
| EH | 0.003 | 0.003 |
| F | 0.85 | 0.35 (0.85)b |
| tlag (h) | 0.1 | 0.1 |
| kf (h-1) | 0.67 | 0.67 |
| CL (l/h/kg) | 1.2 | 0.20 (0.35)b |
a
Rats were treated with a single oral dose of pure matrine (15 mg/kg) or ACAPHA (3.8 or 0.38 g/kg). ka, the absorption rate constant; CL, the renal clearance of matrine.
b
These parameters were optimized based on the experimental data of the ACAPHA studies; parameter values in brackets were for the 0.38 g/kg ACAPHA study.