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. 2009 Jan 21;37(4):900–908. doi: 10.1124/dmd.108.025130

Fig. 6.

Fig. 6.

Effects of NB-598 and Ro 48-8071 treatments on sterol biosynthesis in HepG2 cells. A and B, HepG2 cells were incubated for 24 h with medium containing 0.1% DMSO, 30 μM rifampicin (Rif), or 0.1 to 10 μM NB-598 (A) or with 0.1% DMSO (0, 0), 10 μM Ro 48-8071, 0.1 μM NB-598, or Ro 48-8071 and NB-598 in combination (B). After treatment and metabolic labeling with [14C]MVA, cells were harvested for evaluation of nonsaponifiable lipid contents by thin-layer chromatography and autoradiography as described under Materials and Methods.