TABLE 3.

AUC for each major metabolite

Analyte	AUCa
	5 mg/kg	25 mg/kg	125 mg/kg	250 mg/kg
	μM-h	μM-h	μM-h	μM-h
ATR	0.68	0.54	2.0	9.6
DE	0.92	2.0	10	38
DIP	1.1	2.5	13	58
DACTb	18 (7.5)	140 (4.8)	750 (35)	1250 (42)

^aObtained from the 0- to 24-h plasma concentration data using the trapezoid function in SigmaPlot (Systat Software, Inc., San Jose, CA).

^bEstimated plasma half-lives (h) for DACT are indicated by values in parentheses: data were estimated from the 0- to 24-h time period (Fig. 2B).