Figure 3. HSP90 inhibitors suppress TS-mediated induction of CYP1A1 and CYP1B1 mRNA.
MSK-Leuk1 and KYSE450 cells were treated with the indicated concentrations of 17-AAG or celastrol for 2 h. Subsequently, cells received vehicle or TS for 3 h. RT-PCR was used to determine the amounts of CYP1A1 (panel A), CYP1B1 (panel B) and β-actin mRNAs.