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. 2009 Mar 31;10(4):1445–1464. doi: 10.3390/ijms10041445

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© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Figure 7. — Knockdown of p53 protects HMNCs against MG/HG-induced apoptosis.

HMNCs were transfected with siRNA targeting p53, incubated for 24 h, and treated with MG (5 μM) and HG (15 mM) for a further 24 h. (A) The mRNA levels of p53 and p21 were analyzed using real-time PCR. (B) Cell apoptosis was measured as described in Figure 1. ***P < 0.001 versus the untreated control group. #P < 0.001 versus the “MG + HG” group.