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Knockdown of p53 protects HMNCs against MG/HG-induced apoptosis.
HMNCs were transfected with siRNA targeting p53, incubated for 24 h, and treated with MG (5 μM) and HG (15 mM) for a further 24 h. (A) The mRNA levels of p53 and p21 were analyzed using real-time PCR. (B) Cell apoptosis was measured as described in Figure 1. ***P < 0.001 versus the untreated control group. #P < 0.001 versus the “MG + HG” group.
