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. 2009 Apr 21;10(4):1788–1807. doi: 10.3390/ijms10041788

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© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Figure 1. — Fragments of HIV-RNA and M2-RNA, used as substrates in the non-enzymatic cleavage/ligation (recombination) reaction. Regions of RNAs, complementary to the oligodeoxyribonucleotide template, are highlighted in red. Arrows show internucleotide linkages most susceptible to cleavage (“fragile” sites) [13,16].