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. Author manuscript; available in PMC: 2009 Aug 27.
Published in final edited form as: Circ Res. 2009 Jan 2;104(4):455–465. doi: 10.1161/CIRCRESAHA.108.182568

Fig. 4. Npc1 mutation- or cholesterol-mediated Ctsk induction is inhibited by chemical p38 inhibition or genetic p38 deletion.

Fig. 4

mRNA levels measured in ConA-elicited peritoneal macrophages by quantitative PCR and normalized to ribosomal 36B4. A, C. Cells treated with different inhibitors (10 uM) or DMSO for 24 hrs. *P<0.05 vs. wt/DMSO, #P<0.05 vs. Npc1−/−/DMSO. B. Cells treated with 10 uM SB202190 for indicated time. D, E. wt or p38α−/− cells treated with 50 ug/ml AcLDL±10 ug/ml ACAT inhibitor 58035 for 18 hrs, 5 mM CD-chol (2.5:1, M:M) for 24 hrs, or untreated (CTR). *P<0.05 vs. wt CTR, #P<0.05 vs. wt-CD-chol, §P<0.05 vs. p38α−/− CTR.