Figure 5.

Intersubunit contacts in the β2m_holo hexamer. Views of the strand-strand (a,b) and sheet-sheet (c,d) interfaces within the context of the hexamer. Interfaces correspond to the junction between the green and blue chains shown in Figure 4b,c. Stick representations in a and c are shown as wall-eye stereo pairs. Side chains and annotations are shown only for residues discussed in the main text and for only a single subunit, as the interfaces are approximately two-fold symmetric. (b,d) Surface cutaway of the strand-strand (b) and sheet-sheet (d) interfaces. One subunit is represented as a solvent-accessible surface in green, the other with sticks in blue. Dark-green surface residues correspond to interface participants. For interface residues that have moved >2 Å r.m.s. relative to wild-type β2m_apo (PDB 2CLR), side chains of wild-type β2m_apo are also drawn (gray), with their position in H13F_holo indicated by arrows.