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. Author manuscript; available in PMC: 2009 Oct 15.
Published in final edited form as: Cancer Res. 2009 Apr 7;69(8):3374–3381. doi: 10.1158/0008-5472.CAN-08-4290

Table 1.

Effect of thrombin or hirudin on spontaneous tumor growth in transgenic mice

A. Effect of thrombin on spontaneous tumor growth of prostate adenocarcinoma in TRAMP mice*
n Pos/total Tumor area DXD, mm2 % Tumor n Prostate tumor weight, grams
PBS 9 2/9 0.014 ± 0.01 11 ± 9 6 0.19 ± 0.04
Thrombin 9 7/9 0.42 ± 0.22 62 ± 15 6 1.46 ± 0.74
Fold increase 3× 5.6× 7.7×
P 0.028+ 0.020 0.035 0.028
B. Effect of hirudin on spontaneous tumor growth of prostate adenocarcinoma in TRAMP mice †
n Pos/total Tumor area DXD, mm2 % Tumor Prostate tumor weight, grams
PBS 12 7/10 1.06 ± 0.38 50.9 ± 16.1 6.42 ± 1.03
Hirudin 10 4/12 0.14 ± 0.01 2.12 ± 1.12 0.51 ± 0.11
Fold decrease 7.6× 24× 12.6×
P 0.09+ 0.03 0.03 0.04

Abbreviations: DXD, diameter × diameter of tumor sections examined. % tumor, % tumor in total prostate.

*

C57BL/6 TRAMP mice were injected i.p. every other day starting at 6 wk with PBS or 25 units/kg thrombin for 140 d. SE is given. P, Wilcoxon signed-rank test unless noted with +, which indicates Fisher's exact test (140 d).

†

C57BL/6 TRAMP mice were injected i.p. every other day starting at 6 wk with PBS or 10 mg/kg hirudin. Treatment time varied at 8 d (C57BL/6), 120, and 175 d (C57BL/6FVB). P, Wilcoxon signed-rank test unless noted with +, which indicates Fisher's exact test (140 and 175 d).