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. Author manuscript; available in PMC: 2010 Jun 1.
Published in final edited form as: Antiviral Res. 2009 Feb 21;82(3):110–114. doi: 10.1016/j.antiviral.2009.02.190

Table 1.

Inhibition of dengue virus in cell-based replication assays

Compound Structure EC50a (μM) CC50b (μM) Slc
ARDP0006 graphic file with name nihms97366t1.jpg 4.2 ± 1.9 69 ±4 16.6
ARDP0009 graphic file with name nihms97366t2.jpg 35 ± 8 >300 >8.6
Ribavirin (non-protease Inhibitor) graphic file with name nihms97366t3.jpg 37 ± 1 >300 >8.1
a

EC50 represents the concentration at which the ELISA signal has been reduced 50% in the cell-based replication assay.

b

CC50 represents the concentration at which 50% of the cells have died in the toxicity (MTT) assay.

c

SI (selectivity index) represents the CC50 divided by the EC50.