Table 1.
Compound | Structure | EC50a (μM) | CC50b (μM) | Slc |
---|---|---|---|---|
ARDP0006 | 4.2 ± 1.9 | 69 ±4 | 16.6 | |
ARDP0009 | 35 ± 8 | >300 | >8.6 | |
Ribavirin (non-protease Inhibitor) | 37 ± 1 | >300 | >8.1 |
EC50 represents the concentration at which the ELISA signal has been reduced 50% in the cell-based replication assay.
CC50 represents the concentration at which 50% of the cells have died in the toxicity (MTT) assay.
SI (selectivity index) represents the CC50 divided by the EC50.