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. Author manuscript; available in PMC: 2010 May 18.
Published in final edited form as: Vaccine. 2009 Apr 5;27(23):3026–3034. doi: 10.1016/j.vaccine.2009.03.036

Figure 2. Decreased organ bacterial load in lactoferrin vaccinated mice post-challenge with virulent MTB.

Figure 2

C57BL/6 mice were immunized with BCG, or with BCG and indicated lactoferrins, and aerosol challenged with <100 CFU Erdman MTB. Mice were assessed for organ bacterial load after 30 days. Mice immunized with BCG and human sialylated lactoferrin (rhLF-Sial) showed the greatest reductions in lung CFU, with reduced dissemination to other tissue. Comparisons are shown against non-immunized mice, immunization with BCG alone, human milk-derived lactoferrin (hLF), or with the non-sialylated form (rhLF-UnS). Results are shown as average ± standard deviation for 5–10 mice per group. *p<0.05, compared to non-immunized controls.