Table 10.
Associations between GLO1 genotype and breast cancer according to menopausal status and tumor stage
| AA | AE | EE | AE and EE | |
| Premenopausal | ||||
| Controls, n (%) | 104 (45.2) | 88 (38.3) | 38 (16.5) | 126 (54.8) |
| Cases by stage | ||||
| Local, n (%) | 26 (23.6) | 50 (45.4) | 34 (31.0) | 84 (76.4) |
| OR (95% CI)a | 1.0 | 2.17 (1.16–4.0) | 3.58 (1.82–7.08)b | 2.66 (1.58–4.57) |
| Advanced, n (%) | 13 (16.9) | 34 (44.1) | 30 (39.0) | 64 (83.1) |
| OR (95% CI)a | 1.0 | 3.05 (1.35–6.65) | 6.29 (2.78–14.34)c | 4.08 (2.02–4.20) |
| Postmenopausal | ||||
| Controls, n (%) | 213 (67.8) | 71 (22.6) | 30 (9.6) | 101 (32.2) |
| Cases by stage | ||||
| Local, n (%) | 55 (24.1) | 98 (43.0) | 75 (32.9) | 173 (75.9) |
| OR (95% CI)a | 1.0 | 5.31 (3.39–8.25) | 9.64 (5.59–16.82)d | 6.63 (4.43–9.95) |
| Advanced, n (%) | 25 (19.0) | 79 (59.8) | 28 (21.2) | 107 (81.0) |
| OR (95% CI)a | 1.0 | 9.44 (5.40–16.55) | 7.99 (3.95–16.30)e | 8.66 (4.89–15.20) |
aAdjusted for age, age at menarche, age at FFTP, number of full term pregnancies, first-degree family history of breast cancer, history of benign breast disease, use of oral contraceptives, WHR, alcohol consumption, smoking habits, level of education and postmenopausal use of estrogen. b, c, d, eP for trend = 0.001.