Table 11.
Risk's level according to genotypes combination
| Cases | Controls | ||||
|---|---|---|---|---|---|
| Genotype | n | n | ORa | 95% CI | P |
| Reference genotype | 254 | 633 | 1.0 | ||
| Intermediate risk | 643 | 776 | 2.32 | 1.79–2.54 | < 0.001 |
| High risk | 1291 | 767 | 4.22 | 3.55–5.02 | < 0.001 |
aAdjusted for age, age at menarche, age at FFTP, number of full term pregnancies, first-degree family history of breast cancer, history of benign breast disease, use of oral contraceptives, WHR, alcohol consumption, smoking habits, level of education and postmenopausal use of estrogen. ORs are calculated relative to subjects with the reference genotype.
Reference genotype GSTP1ValVal-PON1/192RR-PON1/55LL-GLO1AA.
Intermediate risk: GSTP1IleVal-PON1/192QR-PON1/55LM-GLO1AE.
High risk: GSTP1IleIle-PON1/192QQ-PON1/55MM-GLO1EE.