Table 7.
Association of genotypes for the PON1 Q192R and PON1 L55M SNPs and breast cancer
| QR | RR | QR and RR | ||
| PON1 Q192R | ||||
| All | ||||
| Cases, n (%) | 484 (88.5) | 50 (9.1) | 13 (2.4) | 63 (11.5) |
| Controls, n (%) | 340 (62.5) | 152 (28.0) | 52 (9.5) | 204 (37.5) |
| OR (95% CI)a | 1.0 | 0.58 (0.32–0.99) | 0.45 (0.18–0.88)b | 0.55 (0.30–0.95) |
| Menopausal status at diagnosis | ||||
| Premenopausal | ||||
| Cases, n (%) | 135 (72.2) | 41 (21.9) | 11 (5.9) | 52 (27.8) |
| Controls, n (%) | 144 (62.6) | 64 (27.8) | 22 (9.6) | 86 (37.4) |
| OR (95% CI) a | 1.0 | 0.73 (0.51–1.43) | 0.64 (0.40–1.44)b | 0.68 (0.47–1.47) |
| Postmenopausal | ||||
| Cases, n (%) | 349 (96.9) | 9 (2.5) | 2 (0.6) | 11 (3.1) |
| Controls, n (%) | 196 (62.4) | 88 (28.0) | 30 (9.6) | 118 (37.6) |
| OR (95% CI) a | 1.0 | 0.12 (0.01–0.33) | 0.08 (0.01–0.14)b | 0.05 (0.02–0.12) |
| PON1 L55M | LL | LM | MM | LM and MM |
| All | ||||
| Cases, n (%) | 107 (19.6) | 115 (21.0) | 325 (59.4) | 440 (80.4) |
| Controls, n (%) | 188 (34.6) | 125 (23.0) | 231 (42.4) | 356 (65.4) |
| OR (95% CI)a | 1.0 | 1.80 (1.36–2.56) | 2.81 (1.95–3.64)c | 2.42 (1.73–2.99) |
| Menopausal status at diagnosis | ||||
| Premenopausal | ||||
| Cases, n (%) | 30 (16.1) | 33 (17.6) | 124 (66.3) | 157 (83.9) |
| Controls, n (%) | 78 (33.9) | 70 (30.4) | 82 (35.7) | 152 (66.1) |
| OR (95% CI) a | 1.0 | 1.26 (0.66–2.39) | 3.83 (2.15–5.87)c | 2.67 (1.62–4.15) |
| Postmenopausal | ||||
| Cases, n (%) | 77 (21.4) | 82 (22.8) | 201(55.8) | 283 (78.6) |
| Controls, n (%) | 110 (35.0) | 55 (17.5) | 149 (47.5) | 204 (65.0) |
| OR (95% CI) a | 1.0 | 2.23 (1.39–3.40) | 2.06 (1.30–2.97)c | 2.59 (1.35–3.06) |
aAdjusted for age, age at menarche, age at FFTP, number of full term pregnancies, first-degree family history of breast cancer, history of benign breast disease, use of oral contraceptives, WHR, alcohol consumption, smoking habits, level of education and postmenopausal use of estrogen. bP for trend: all, 0.01; premenopausal, 0.29; postmenopausal, 0.001. cP for trend: all, premenopausal, postmenopausal, 0.001.