Figure 8.
The microglia/macrophage (F4/80) response is increased in C1q KO mice 3 d post-SCI. A, No significant differences in the percentage of neutrophils in the spinal cords were noted between C1q KO (n = 4) and WT (n = 4) mice 1 d post-SCI (Student's t test, p > 0.05). B, Additionally, no significant differences in the percentage of neutrophils were noted between C1q KO (n = 6) and WT (n = 5) mice 3 d post-SCI (Student's t test, p > 0.05). C, C1q KO (n = 9) mice showed a significant increase in the percentage of F4/80-positive microglia/macrophage compared with WT (n = 6) mice 3 d post-SCI (Student's t test, *p < 0.01). Bars represent group means ± SEM. D, Representative scatter plots of spinal cord cells labeled with either F4/80 antibody or isotype control.