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. Author manuscript; available in PMC: 2010 May 1.
Published in final edited form as: Eur J Radiol. 2009 Mar 4;70(2):265–273. doi: 10.1016/j.ejrad.2009.01.043

Figure 2.

Figure 2

Radiohybridization and MRI probes

a. 99mTc-PNA-Peptide probe with IGF1 analog specific for IGF1 receptor, PNA sequence complementary to CCND1 oncogene mRNA, and N4 chelating peptide GdAGG for chelating 99mTc for SPECT imaging of breast cancer.

b. SBTG2-KRAS PNA-Peptide probe with IGF1 analog specific for IGF1 receptor, PNA sequence complementary to KRAS D12 mutant, and N2S2 chelator for 99mTc or 64Cu for SPECT or PET imaging of pancreatic cancer.

c. MRI probe with IGF1 analog specific for IGF1 receptor, PNA sequence complementary to KRAS D12 mutant, and DOTA for chelating Gd for MRI of pancreatic cancer.