Skip to main content
. Author manuscript; available in PMC: 2009 Dec 8.
Published in final edited form as: Cancer Lett. 2008 Aug 12;272(1):91–101. doi: 10.1016/j.canlet.2008.06.032

Fig. 3.

Fig. 3

Effect of GSK3β-mediated nuclear localization of survivin on cell cycle progression in A549 cells. A, representative histographs of the cell cycle analysis of A549, following 24 h treatment with various concentrations of LiCl. B, calculation of cell populations (%) in different cell-cycle phases (G1, S and G2/M) for (A). C, representative histographs of cell cycle analysis of A549 transfected with GSK3β mutant plasmids S9A-GSK3β (S9A) and DN-GSK3β (DN). In cells transfected with DN, 10nM Leptomycin B (LMB) was added to the cell culture to block nuclear export of survivin. D, cell populations (%) in different cell-cycle phases (G1, S and G2/M) for (C). Data represent mean ± SD of three independent experiments. Statistical analysis by One-Way ANOVA test for significant differences; *P<0.05.