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. Author manuscript; available in PMC: 2009 Dec 1.
Published in final edited form as: Neuropsychopharmacology. 2009 Jan 28;34(7):1764–1773. doi: 10.1038/npp.2008.234

Figure 1.

Figure 1

Chronic fluoxetine and desipramine treatments elevated cell proliferation in MRL/MpJ mice but not C57BL/6J mice. (a) MRL/MpJ mice were administered saline (n = 15) or fluoxetine (FLX; 2.5, 5, 10 mg/kg b.i.d.; n = 10/group) for 21 days. The 5 and 10 mg/kg doses of FLX increased cell proliferation (F(3,38) = 21.89, P < 0.0001) (b) MRL/MpJ mice were administered saline (n = 15) or desipramine (DMI; 2.5, 5, 10 mg/kg b.i.d.; n = 10/group) for 21 days. DMI (5 and 10 mg/kg) significantly increased cell proliferation (F(3,38) = 8.77, P < 0.001). (c) C57BL/6J mice were administered saline (n = 10) or fluoxetine (FLX; 5 or 10 mg/kg b.i.d.; n = 10/group) for 21 days. FLX did not alter cell proliferation (F(2,21) = 0.60, P = 0.56). (d) C57BL/6J mice were administered saline (n = 10) or desipramine (DMI; 5 or 10 mg/kg b.i.d.; n = 10/group) for 21 days. DMI did not increase cell proliferation (F(2,22) = 1.17, P = 0.32). Values are expressed as the number of BrdU positive cells per 10,000 7-AAD events. Bars represent mean values + 1 s.e.m. Asterisks (**) indicate groups that differed significantly from control (P < 0.005) according to Dunnett's test.