Figure 4.
Chronic treatments with fluoxetine or desipramine did not affect the survival of newly born hippocampal progenitor cells. Cells were labeled by administration of BrdU (100 mg/kg i.p. for 4 days) prior to the initiation of chronic treatment. (a) MRL/MpJ mice or (b) C57BL/6J mice (n = 10 mice/group) were administered saline (open bar), fluoxetine (FLX; 5 mg/kg b.i.d.; striped bar), or desipramine (DMI; 5 mg/kg b.i.d.; dotted bar) for 21 days. Values for ANOVA were not statistically significant (P > 0.05). Values are expressed as the number of BrdU positive cells per 10,000 7-AAD events. Bars represent mean values + 1 s.e.m.