Figure 4. Magnetic nano-sensors enumerate monocyte subset variations that occur in atherosclerotic patients.
A. Representative flow cytometry dot plots of monocyte subsets from healthy volunteers and patients with documented coronary artery disease (CAD). Numbers depict percentage of subsets in both groups. MeanĀ±SEM. B. Plots depict percentage (left plot) and absolute numbers (right plot) of CD16lo and CD16hi monocytes from healthy volunteers (green dots) and patients with CAD (red dots). C. Validation of the enumerative mathematical model with varying number and percentage of monocyte subsets. Data show goodness of fit of defined numbers of monocytes alone (left panel), other leukocytes (middle-left panel) and combinations of leukocytes and monocytes (right two panels). Different proportions of monocyte subsets (CD16lo/CD16hi (%)) are color-coded and their fit is depicted on the two-dimensional T2 maps.