Table 1. Clinical symptoms in the siblings of the HHS-affected family.

Symptoms\Siblings	S1	S2	S3	S4	S5
Skin pigmentation	−	+1	−	−	−
Nail dystrophy	−	+	+	+	+
Leukoplakia	−	+	+	+	+
Bone marrow failure	−	+	+	+	+
T+ B− NK− immunodeficiency	−	+	+	+	+
Intrauterine growth retardation	−	+	+	+	−
Growth retardation	−	−	+	+	+
Microcephaly	−	+	+	+	+
Cerebellar hypoplasia/dysfunction	−	+	+	+2	+2
Pancytopenia	−	+	+	+	+
Infections	−	+	+	+	+
Esophageal atresia	−	+	+3	+3	+3

¹Mild pigmentation was observed.

²Cerebellar hypoplasia was confirmed by imaging.

³History of major difficulties in swallowing solid food; not confirmed by imaging.