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. Author manuscript; available in PMC: 2009 May 13.
Published in final edited form as: Free Radic Biol Med. 2007 Dec 27;44(7):1246–1258. doi: 10.1016/j.freeradbiomed.2007.12.027

Figure 3. Diagram of the free radical hypothesis of silica toxicity in the alveolar macrophage.

Figure 3

An overview of the effect of silica (SiO2 indicated with surface oxygen radical) endocytosis; the consequential respiratory burst, the signal transduction resulting in inflammatory cytokine release, and the antioxidant compensatory mechanisms are illustrated in this figure.