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. 2009 May 29;5(5):e1000445. doi: 10.1371/journal.ppat.1000445

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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A. ID₅₀ values of HIV-2 neutralization by rabbit immune sera, performed in the absence and presence of sCD4. The statistical significance (p value) of the increase in HIV-2-neutralization titer (in the presence of sCD4) with the increase in the number of stabilizing cysteines (2CC, 3CC, 4CC) was analyzed by Mann-Whitney test. B. Linear regression analysis showing correlations of HIV-2-neutralization titer with kinetic and thermodynamic parameters. Left, with reciprocal of affinity (1/k_D); middle, with reciprocal of the association rate constant (1/k_a); right, with the percent of epitope stabilization, as measured from the entropy change (−TΔS) relative to that of coreV3S.