Figure 3.
Expression Profiling and Metabolic Studies in WT and RIP140 Null Mice
(A) Cluster analysis of genes significantly altered in the null muscle tissue with a significance value of p < 0.01 with a specific defined role in muscle cell development, structure, or function. Red and green colors indicate relative expression levels (red = increased expression, green = reduced expression).
(B) Cluster analysis of genes significantly altered in the null muscle tissue with a significance value of p < 0.01 with a specific defined role in metabolic pathways (red = increased expression, green = reduced expression).
(C) Forty-eight hour profile of oxygen consumption in WT and RIP140 null (KO) mice (n = 6) maintained on normal diet. Data are expressed as mean ± SEM.
(D) Forty-eight hour profile of oxygen consumption in WT and RIP140 null (KO) mice (n = 6) maintained on high-fat diet. Data are expressed as mean ± SEM.
(E) Forty-eight hour profile respiratory exchange ratio (RER) in WT and RIP140 null (KO) mice maintained on a normal diet. Data are expressed as mean ± SEM.
(F) Forty-eight hour profile RER in WT and RIP140 null (KO) mice maintained on a high-fat diet. Data are expressed as mean ± SEM.