Table 3.
Average Results from Single-SNP Meta-Analyses of Simulated Data Replicates
| SNP 1 |
SNP 2 |
SNP 3 |
SNP 4 |
SNP 5 |
|
|---|---|---|---|---|---|
| Number of studies |
7 |
4 |
13 |
1 |
7 |
| True OR | 1 | 1.5 | 1 | 1 | 1 |
| Proportion significanta | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| Mean OR (SE) | 0.82(0.01) | 1.51(0.02) | 1.38(0.01) | 1.39(0.02) | 0.78(0.01) |
| Mean CI length | 0.14 | 0.34 | 0.15 | 0.38 | 0.13 |
| True OR | 1 | 1.25 | 1 | 1 | 1 |
| Proportion significanta | 0.65 | 0.95 | 1.00 | 0.80 | 0.80 |
| Mean OR (SE) | 0.90(0.01) | 1.26(0.02) | 1.19(0.01) | 1.2(0.02) | 0.87(0.01) |
| Mean CI length | 0.15 | 0.30 | 0.13 | 0.34 | 0.15 |
| True OR | 1 | 2 | 1 | 1 | 1 |
| Proportion significanta | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| Mean OR (SE) | 0.70(0.01) | 2.03(0.02) | 1.74(0.01) | 1.76(0.03) | 0.66(0.01) |
| Mean CI length | 0.12 | 0.46 | 0.19 | 0.48 | 0.11 |
For each scenario results are means (SE) of the OR estimate over 20 analyses of replicate data sets simulated under identical conditions.
a
Proportion of replicates in which the SNP is significant at the 5% level.