Table 6.
Average Results from Bayesian Multi-SNP Meta-Analyses of Simulated Data Replicates
| SNP 1 |
SNP 2 |
SNP 3 |
SNP 4 |
SNP 5 |
σHap |
|
|---|---|---|---|---|---|---|
| No. Studies |
7 |
4 |
13 |
1 |
– |
|
| True OR | 1 | 1 | 1 | 1 | 1.5 | – |
| Mean posterior probability (SE) | 0.03(0.04) | 0.03(0.05) | 0.01(<0.01) | < 0.01(0.01) | 1.00(<0.01) | 1.00(0) |
| Mean OR (SE) | 1.00(<0.01) | 1.00(<0.01) | 1.00(<0.01) | 1.00(<0.01) | 1.50(0.04) | 0.12(0.02)a |
| Mean BCI length | 0.02 | 0.03 | < 0.01 | < 0.01 | 0.18 | 0.10 |
| Mean OR present (SE)b | 1.00(0.05) | 1.04(0.07) | 1.03(0.03) | 1.03(0.05) | 1.50(0.04) | 0.12(0.02)a |
| Mean BCI length presentb | 0.14 | 0.22 | 0.18 | 0.14 | 0.18 | 0.10 |
| True OR | 1 | 1.5 | 1 | 1 | 1.5 | – |
| Mean posterior probability (SE) | 0.03(0.08) | 0.95(0.22) | 0.01(0.02) | 0.08(0.25) | 1.00(<0.01) | 1.00(0) |
| Mean OR (SE) | 1.00(<0.01) | 1.51(0.18) | 1.00(<0.01) | 1.01(0.09) | 1.52(0.1) | 0.11(0.02)a |
| Mean BCI length | 0.02 | 0.53 | 0.02 | 0.04 | 0.47 | 0.10 |
| Mean OR present (SE)b | 1.02(0.06) | 1.52(0.16) | 1.01(0.09) | 1.00(0.12) | 1.52(0.10) | 0.11(0.02)a |
| Mean BCI length presentb | 0.14 | 0.53 | 0.27 | 0.25 | 0.47 | 0.10 |
For each scenario, results are means (SE) of estimators over 20 analyses of replicate data sets simulated under identical conditions. In each analysis, OR estimates were taken as the median of the posterior sample.
a
These are point estimates of σHap and therefore are not ORs.
b
Calculated on the condition that the SNP was included in a model.