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. Author manuscript; available in PMC: 2009 Sep 1.
Published in final edited form as: Nat Genet. 2009 Feb 8;41(3):334–341. doi: 10.1038/ng.327

Figure 3. Plot of observed versus expected P value distribution for association of 554 common copy number variants with early-onset myocardial infarction.

Figure 3

The CANARY algorithm was used to test 554 commonly segregating CNVs (> 1% frequency) for association with early-onset MI in 2,783 cases and 2,865 controls that passed sample quality control for CNV analysis (Methods). The estimated genomic control lambda for the entire set of CNVs was ~1.23; for 316 CNVs with allele frequency greater than 5%, lambda was ~1.05. We did not observe any CNV with evidence for association surpassing our pre-specified threshold for replication of P < 0.001. The observed versus expected P value distribution did not show deviation from the null distribution.