Table 1. Participant characteristics of case and control subjects in Stage 1 of the genome-wide association screen.
| Study | Italian ATVB Study | Heart Attack Risk in Puget Sound | REGICOR | MGH Premature Coronary Artery Disease Study | FINRISK | Malmö Diet and Cancer Study | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||||
| cases | controls | cases | controls | cases | controls | cases | controls | cases | controls | cases | controls | |
| N | 1,693 | 1,668 | 505 | 559 | 312 | 317 | 204 | 260 | 167 | 172 | 86 | 99 |
|
Ascertainment scheme |
hospital- based |
hospital- based |
community- based |
community- based |
hospital- based |
drawn from community-based cohort | hospital- based |
hospital- based |
drawn from population-based cohort | nested case-cohort | drawn from population-based cohort | nested case-cohort |
|
MI age criterion |
men or women ≤ 45 | -- | men ≤50 or women ≤ 60 | -- | men ≤50 or women ≤ 60 | -- | men ≤50 or women ≤ 60 | -- | men ≤50 or women ≤ 60 | -- | men ≤50 or women ≤ 60 | -- |
| Country of origin * | Italy | Italy | U.S. | U.S. | Spain | Spain | U.S. | U.S. | Finland | Finland | Sweden | Sweden |
| Mean age (y) † | 39.4 ± 4.9 | 39.3 ± 5.0 | 46.0 ± 6.9 | 45.2 ± 7.3 | 45.9 ± 5.8 | 46.0 ± 5.6 | 47.0 ± 6.1 | 53.8 ± 11.1 | 47.1 ± 6.2 | 47.1 ± 6.0 | 48.5 ± 4.4 | 48.7 ± 4.6 |
|
Female gender (%) |
11.4 | 11.6 | 51.1 | 55.5 | 20.2 | 21.5 | 29.9 | 33.5 | 33.5 | 31.4 | 41.9 | 42.4 |
| Ever cigarette smoking (%) | 87.0 | 49.3 | 73.9 | 41.7 | 82.8 | 61.9 | 74.9 | 57.3 | 74.4 | 58.2 | 87.2 | 61.6 |
|
Hypertension (%) ‡ |
32.6 | 11.9 | 50.5 | 30.8 | 38.0 | 31.5 | 33.5 | 25.3 | 72.5 | 68.0 | 81.4 | 62.6 |
| Diabetes mellitus (%) § | 7.8 | 0.8 | 14.9 | 3.0 | 14.8 | 6.1 | 19.2 | 0.4 | 17.7 | 5.9 | 4.7 | 1.0 |
|
Hypercholest erolemia (%) ¶ |
60.4 | 44.4 | 43.7 | 26.0 | 48.9 | 33.1 | 79.0 | 31.3 | 75.2 | 48.2 | 37.2 | 1.0 |
| Body mass index (kg/m2) | 26.7 ± 4.2 | 25.0 ± 3.3 | 29.2 ± 6.8 | 26.9 ± 5.7 | 27.5 ± 4.2 | 27.0 ± 3.9 | 30.0 ± 7.0 | 27.9 ± 6.5 | 29.6 ± 5.0 | 27.7 ± 4.0 | 26.9 ± 4.2 | 25.7 ± 4.3 |
Values with ‘±’ are means ± s.d. The body-mass index is the weight in kilograms divided by the square of the height in meters.
*
All cases and controls were of European ancestry.
†
Mean age at MI for cases and at age of recruitment for controls
‡
Hypertension was defined as a previous diagnosis of hypertension, on anti-hypertensive therapy, or with recorded systolic blood pressure ≥ 140 mmHg or diastolic blood pressure ≥ 90 mmgHg.
§
Diabetes mellitus was defined as a previous diagnosis of diabetes or treatment with anti-diabetic medications.
¶
Hypercholesterolemia was defined as a previous diagnosis of hypercholesterolemia or treatment with lipid-lowering therapy