. Author manuscript; available in PMC: 2009 Sep 1.

Published in final edited form as: Nat Genet. 2009 Feb 8;41(3):334–341. doi: 10.1038/ng.327

Table 3. Quintiles of allelic dosage score comprised of eight validated MI single nucleotide polymorphisms and risk for early-onset myocardial infarction.

Quintile of MI Genotype Score	Odds ratio	95% confidence interval
Quintile 1	1.0 (reference group)
Quintile 2	1.10	0.93 - 1.29
Quintile 3	1.41	1.20 - 1.65
Quintile 4	1.60	1.36 - 1.89
Quintile 5	2.05	1.74 - 2.42
P for association of MI genotype score with early-onset MI: 4 × 10^-25

The eight validated MI polymorphisms are as shown in Table 2 and include PHACTR1 rs12526453, SLC5A3/MRPS6/KCNE2 rs9982601, 9p21.3 rs4977574, CXCL12 rs1746048, CELSR2/PSRC1/SORT1 rs646776, MIA3 rs17465637, LDLRs rs1122608, and PCKS9 rs11206510. Risk of early-onset MI was assessed in the 2,967 cases and 3,075 controls from Stage 1.